Thinning is key on your first and last coats! Thin 50/50 on your first coat to ensure it soaks in to all the 'nooks & crannies' & thin down your last coat about 10% to get a smooth, perfect finish!
Foam brushes are your friends... Sometimes. Have a handful of them for all the base work, but ensure you have a really high quality brush for your later layers.
Heat guns: When you figure out how to work yours, that tedious task you put off all winter of removing old layers becomes a breeze. Practice makes perfect - start on an inconspicuous spot while you get the hang of it!
Sand with the grain! An oldy but a goody - this is absolutely essential for a good starting point. And don't be afraid to really get in there with a rough grit. Random orbital sanders are a great way to get started, but finish up with a sanding block.
Combine your Varnish (well not literally..): Interlux Rep Tim Taylor suggested using both Schooner & Schooner Gold as his recipe for a perfect job! Alternate between them on your layers (how many layers, you ask, 7-10!!)
Interprotect is your friend! If you are going to start fresh from the bare fiberglass, put on 4-5 coats to have an awesome substrate to start on.
The VCs are your top choice for a smooth, racing hull, but just don't have the 'Umph' to do it alone here on the East Coast, so make sure you are hauling for a good scrub at least once every month or two.
Starting Fresh? Consider using a different colour for your first coat. That way, as your antifouling begins to wear off, you'll know. This is especially useful when using an ablative like Micron CSC or Bottomkote ACT.
Choose anything but XXX: Yes, straight from the horses mouth! If you are applying antifouling, and you do not currently have XXX (over which you cannot apply any other type), DO NOT use Bottomkote XXX. While it is cost-effective up-front, the cost over time will add up as it is not ablative nor multi-season, and leaves a nasty job when it's time to start fresh.
When in doubt, DO NOT paint! The Tip we think you'll love the most. If you haul your boat and your antifouling is still in good condition, do NOT apply more. This causes layers to build up and then simply fall off, instead of doing their job.